DOREMI
Low dose research towards multidisciplinary integration
Informazioni Generali
- Coordinatore:
- STUK RADIATION AND NUCLEAR SAFETY AUTHORITY (Finlandia)
- Responsabile:
- SARAN ANNA - SSPT-TECS-TEB (CASACCIA)
- Ruolo ENEA:
- PARTNER
- Sito WEB:
- Sito WEB non disponibile
Programmi Europei
- Programma:
- Settimo Programma Quadro Euratom (2007-2013) -> Euratom fissione (NOE - Rete di Eccellenza)
Descrizione e Attività
Descrizione Generale
The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (http://www.hleg.de. DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initiative) consisting of major national bodies and research programmes that have long term commitment in low dose risk research in Europe. A Letter of Intent between the core members of MELODI has been signed in April 2009. During the project, new members are expected to join the Initiative.
The Joint Programme of Activities (JPA) of DoReMi includes:
- A Joint Programme of Research (JPR) covering the issues outlined above and providing an overview of the needs for research infra-structures of pan-European interest and facilitating multilateral initiatives leading to better use and development of research infrastructures
- A Joint Programme of Integration (JPI) to develop a coor-dinated European roadmap for the long term needs of the key players in Europe
- A Joint Pro-gramme for the Spreading of Excellence (JPSE), covering knowledge management, training and mo-bility and its implementation
The JPR focuses on the areas identified by the HLEG as the most prom-ising in terms of addressing/resolving the key policy questions, namely: the shape of dose response curve for cancer, individual susceptibilities and non-cancer effects. Radiation quality, tissue sensitivity and internal exposures will be addressed as cross cutting themes within the three main research areas. A substantial proportion of the JPA will be dedicated to the joint programme of research. The pro-gramme describes a multidisciplinary approach including interfaces with the broader biological toxico-logical and epidemiological communities. Strategic planning will be carried out in close collaboration with MELODI.
Attività svolta da ENEA
L'ENEA si occuperà di valutare in vivo, utilizzando un modello animale molto sensibile agli effetti delle radiazioni, l'incidenza di tumori cerebellari dopo irraggiamento con raggi gamma a basso rateo di dose. Saranno, inoltre, studiati i meccanismi molecolari implicati nello sviluppo del tumore. In queste ricerche si utilizzerà una particolare facility giapponese in esercizio presso l'Institute for Environmental Sciences (IES) di Rokkasho-Mura, nell'ambito di un accordo in vigore con tale istituto.