Dati Progetto

Num. Contratto

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FI6R-CT-2003-508842

Coordinatore

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CEA - COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (Francia)

Responsabile ENEA

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SARAN ANNA - SSPT-TECS-TEB (CASACCIA)

Sito WEB

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Sito WEB non disponibile

Descrizione

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Radiation protection requires a thorough understanding of low dose ionising radiation. Currently extrapolation from high doses is necessary to estimate the effects of low doses. Furthermore, it is critically important to have an appreciation of the variation in individual responses to radiation among the human population. Present estimates of the risks from radiation exposure are based largely on the "average" individual in an exposed population. However, clinical observations of adverse reactions to radiotherapy indicate large variations in individual radio sensitivity. Quantification of risk requires the identification of new parameters taking into account these differences in radiation responses. Therefore, a detailed knowledge of the mechanisms by which radiation induces cancer is essential. In this project, leading European research teams join forces to understand the various steps involved in the multistage process of radiation-induced tumorigenesis through detailed analysis of DNA damage responses (repair, checkpoints, apoptosis), genomic instability as well as mechanisms/genetics and modelling of radiation tumorigenesis. The research in this project will answer the following specific questions: (i) who is at risk? ; (ii) when do the factors modifying risk exert their influence? ; (iii) what are the mechanisms through which risk factors act? ; (iv) Is there a link between radio sensitivity of individuals (short term) and susceptibility to cancer (Late after exposure)? The consortium will apply innovative and state of the art technology (genomic, polemics, advanced fluorescence microscopy, RNA interference, gene knock-in technology). We stress that the identification of genetic variables in the processing of radiation induced DNA damage is vital for re-evaluation of current radio-protective measures and the development of future protective procedures.

Attività svolta da ENEA

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ENEA participates in two of the RISC RAD Workpakages, WP3 and WP4. Work carried out under WP3 primarily aims at providing quantitative data on tumorigenesis due to exposure to low doses of ionizing radiation (down to <100mGy) in a radiation sensitive mouse model carrying mutations in the Patched (Ptc1) gene, the best example of a gene influencing radiation tumor risk in the human population. In addition, work in WP3 is centered on understanding the initiating events in mouse radiation cancer, and the relationships between initial radiation-induced damage to DNA and the appearance of early tumor-associated cellular events, together with their contribution to multistage neoplasia, genetic susceptibility. Work carried out at ENEA under RISC-RAD WP4 investigates the genetic factors in mouse radiation tumorigenesis. Genetic mapping of modifiers of radiation carcinogenesis susceptibility in the Ptc1 mouse model has been carried out through generation and phenotypic characterization of mouse crosses with outbred skin carcinogenesis-resistant and -susceptible (Car-R and Car-S, respectively) mouse lines previously generated by phenotypic selection in the ENEA laboratories, followed by genetic linkage analysis at high resolution. ENEA coordinates the integration proposal with the following objectives: To gain information on the involvement of HR and/or NHEJ in radiation-induced tumorigenesis; to clarify tumor-associated genetic and epigenetic events in radiation-induced medulloblastoma tumorigenesis; to elucidate early/late radiation-associated cytogenetic and molecular events in medulloblastoma tumorigenesis through analysis of preneoplastic cerebellar lesions of different developmental stage; to provide expression profiles of spontaneous and radiation-induced medulloblastomas.

Programma Quadro

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Sesto Programma Quadro EURATOM (2002-2006)

Programma UE

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Euratom radioprotezione

Tipo Progetto

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IP - Progetto Integrato

Riferimenti ENEA

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Posizione: 845

Atto di Approvazione ENEA: 006/2004/BIOTEC - 69/2007/DG

Codice Atto: 07L15 - 07M18

Unità alla stipula: BIOTEC

Dati Finanziari (in euro)

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Costo eleggibile del progetto: 16.319.675,00 Costo eleggibile per ENEA: 633.000,00

Contributo al progetto: 10.227.500,00 Contributo a ENEA: 318.000,00

Durata

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Anno di stipula: 2004

Durata (in mesi): 58

Data di inizio: 01-01-2004

Data di scadenza: 31-10-2008

Partner (29)

Ruolo	Tipologia	Nome	Nazione
	Università	UNIV. SALISBURGO	Austria
	Università	UNIV. AARHUS (AU)	Danimarca
	Istituti di ricerca	STUK RADIATION AND NUCLEAR SAFETY AUTHORITY	Finlandia
	Istituti di ricerca	ASSOCIATION POUR LE DEVELOPPEMENT DE LA PHYSIQUE ATOMIQUE	Francia
COORD	Istituti di ricerca	CEA - COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES	Francia
	Istituti di ricerca	CNRS - FRENCH NATIONAL CENTRE FOR SCIENTIFIC RESEARCH	Francia
	Università	ECOLE NORMALE SUPERIEURE DE LYON	Francia
	Istituti di ricerca	INSERM - NATIONAL INSTITUTE OF HEALTH AND MEDICAL RESEARCH	Francia
	Istituti di ricerca	GSF NATIONAL RESEARCH CENTRE FOR ENVIRONMENT AND HEALTH	Germania
	Università	UNIV. RUPRECHT-KARLS HEIDELBERG	Germania
	Università	UNIV. NATIONAL OF IRELAND - GALWAY	Irlanda
PARTNER	Istituti di ricerca	ENEA	Italia
	Istituti di ricerca	ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI	Italia
	Università	UNIV. PAVIA	Italia
	Altro	ERASMUS MEDICAL CENTER ROTTERDAM	Paesi Bassi
	Istituti di ricerca	NRG - NUCLEAR RESEARCH AND CONSULTANCY GROUP	Paesi Bassi
	Università	UNIV. LEIDEN	Paesi Bassi
	Organismi pubblici NO ricerca	WORLD INSTITUTE FOR HEALTH AND ENVIRONMENT	Paesi Bassi
	Istituti di ricerca	GRAY LABORATORY CANCER RESEARCH TRUST	Regno Unito
	Istituti di ricerca	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	Regno Unito
	Istituti di ricerca	MEDICAL RESEARCH COUNCIL	Regno Unito
	Istituti di ricerca	NATIONAL RADIOLOGICAL PROTECTION BOARD	Regno Unito
	Università	UNIV. BRUNEL LONDON	Regno Unito
	Università	UNIV. CAMBRIDGE	Regno Unito
	Università	UNIV. SUSSEX	Regno Unito
	Istituti di ricerca	CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS	Spagna
	Università	UNIV. AUTONOMA BARCELONA	Spagna
	Università	UNIV. AUTONOMA MADRID (UAM)	Spagna
	Università	UNIV. STOCKHOLM	Svezia

Keyword associate al progetto dal database di CORDIS (8)

Keyword
LIFE SCIENCES
MEDICINE, HEALTH
NUCLEAR FISSION
RADIATION PROTECTION
WASTE MANAGEMENT
COORDINATION, COOPERATION
POLICIES
SCIENTIFIC RESEARCH

Altre Keyword non presenti nel database di CORDIS (2)

Altri indici
Environmental health
Nuclear fusion