METROMRT
Metrology for molecular radioteraphy
Informazioni Generali
- Coordinatore:
- NPL NATIONAL PHYSICAL LABORATORY (Regno Unito)
- Responsabile ENEA:
- D'ARIENZO MARCO - FSN-INMRI (CASACCIA)
- Ruolo ENEA:
- PARTNER
- Sito WEB:
- http://projects.npl.co.uk/metromrt
Descrizione e Attività
Descrizione Generale
Scientific Objectives
• To develop the TDCR Cerenkov technique for primary standard activity measurements of highactivity high-energy beta-emitters (such as 32P, 89Sr, 90Y); the objective is to obtain on the one hand, a primary activity standard for 90Y microspheres based on the TDCR Cerenkov technique, on the other hand, a reliable standard transfer protocol to end-users for 90Y microspheres
• To improve the accuracy of the knowledge of the shape of beta spectra required for activity measurements using the TDCR Cerenkov technique as well as for absorbed dose measurements
• To investigate methods for validation and calibration of quantitative radionuclide imaging with the aim of developing/identifying suitable phantoms for use for dosimetry audits and traceable calibration transfer
To investigate the performance of a range of image reconstruction and correction algorithms
employed for quantitative imaging, using measurements and Monte Carlo simulation, in order to provide objective evidence for preferred methods
• To develop advice and guidelines for standard procedures for quantitative activity measurements and verification/calibration using SPECT-CT and PET-CT
• To investigate possible methodologies for the direct measurement of absorbed energy in a range of suitable media and geometries, from a selected number of radionuclides, for the purposes of achieving measurement traceability to a primary standard of absorbed dose and for validating the dose calculation methods used in patient dosimetry
• To analyse and model the dosimetry chain in order to estimate the uncertainty component in each link, and to assess the implications for the health and medical research communities of reducing these uncertainties.
Attività svolta da ENEA
L'ENEA coordina il WP3 (sviluppo di uno standard primario per la misura della dose assorbita nei trattamenti di radioterapia molecolare necessario alla validazione delle tecniche di valutazione della dose impiegata clinicamente). Partecipa inoltre a tutti gli altri WPs.
Programmi Europei
- Programma:
- Other programmes → EMRP (2007-2013) (N/A - Non applicabile)
Dati Finanziari (in euro)
Costo Eleggibile
- Progetto:
- 2.575.362,00
- ENEA:
- 432.724,00
Contributo
- Al progetto:
- 1.140.885,00
- A ENEA:
- 191.697,00
Durata del Progetto
- Anno di stipula e Durata:
- 2012 - 36 mesi
- Periodo:
- 01-06-2012 → 31-05-2015