NEWCOTIANA
Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques
Informazioni Generali
- Coordinatore:
- CSIC - SPANISH NATIONAL RESEARCH COUNCIL (Spagna)
- Responsabile ENEA:
- GIULIANO GIOVANNI - SSPT-AGROS (CASACCIA)
- Ruolo ENEA:
- PARTNER
- Sito WEB:
- https://newcotiana.webs.upv.es/
Descrizione e Attività
Descrizione Generale
A group of New Plant Breeding Techniques (NPBT) has opened unprecedented opportunities in agriculture. Those NPBTs are at least as efficient and often more precise than previous traditional and GM techniques, while circumventing the introduction of heritable transgenes from distant species in the plant genome. Properly communicated, NPBTs are expected to gain wide acceptance, especially when applied to breeding objectives which are seen as beneficial for the society. A well-perceived objective is Molecular Farming, which refers to the use of plants for the production of valuable biomolecules (e. g. biopharmaceuticals). Cultivated tobacco (Nicotiana tabacum) and its close Australian relative Nicotiana benthamiana, are preferred species in Molecular Farming due to their favourable features: non-food crops, easy tissue regeneration, high productivity, rich secondary metabolism and availability of genetic tools. In sharp contrast, traditional tobacco cultivation is in serious decline in the EU, causing serious social problems in many rural areas. NEWCOTIANA aims to revitalize those areas by breeding efficient Nicotiana biofactories of high-value non-smoking products as alternatives for traditional tobacco crops. NEWCOTIANA will develop the most advanced tobacco NPBTs toolbox, easily transferable to other plants. This will position EU in the avant-garde of breeding innovation. This toolbox will be used to create elite multipurpose Nicotiana varieties improved in product-specific traits (bioproduct quality, stability and yield), next to more general traits as biomass, resilience and biosafety. The “Newcotiana” varieties will be carefully tested in relevant pre-industrial environments for the production of end-value chemicals, namely proteins and metabolites for health and nutriceutical use. Ethical, social and legal aspects will be closely monitored and public and stakeholder engagement will be assured using innovative science communication methodologies.
Attività svolta da ENEA
L'ENEA partecipa ai work package:
. WP1 Nicotiana biofactory NPBT toolbox: completamento della sequenza genomica di Nicotiana al fine di ottimizzare l'applicazione di NPBT;
. WP3 Breeding and evaluation of metabolite biofactory lines: ottimizzazione, tramite NPBT, della produzione di carotenoidi antiossidanti e alcaloidi anti-Alzheimer in foglie di tabacco;
. WP4 Validation and evaluation of NEWCOTIANA biofactories in industrially-relevant settings: verifica dei livelli di produzione di tali sostanze in pieno campo.
Programmi Europei
- Programma:
- HORIZON 2020 → NMBP Nanotechn., Adv Materials, Adv Manufacturing and Processing, and Biotech (RIA - Research and Innovation Action)
Dati Finanziari (in euro)
Costo Eleggibile
- Progetto:
- 7.363.310,00
- ENEA:
- 465.000,00
Contributo
- Al progetto:
- 7.199.560,00
- A ENEA:
- 465.000,00
Durata del Progetto
- Anno di stipula e Durata:
- 2018 - 48 mesi
- Periodo:
- 01-01-2018 → 31-12-2022
Numero di Partner (19)
Keyword associate al progetto dal database di CORDIS (4)
Altre Keyword non presenti nel database di CORDIS (0)
Nessuna altra keyword disponibile per questo progetto
2021 - Rimodulazione dei costi e proroga della scadenza delle attività al 31 dicembre 2022 (60 mesi) (disp. 169/2021/PRES). Rimodulazione dei costi ENEA, ma restano invariati i costi eleggibili rimborsati al 100%, contributo CE a ENEA invariato.