Num. Contratto:
LSHB-CT2006-037639

Coordinatore: ENEA (Italia)

Responsabile ENEA: BORSELLA ELISABETTA - TERIN-DEC-H2V (CASACCIA)

Ruolo ENEA: COORD

Sito Web: Sito WEB non disponibile

Programma Quadro: Sesto Programma Quadro UE (2002-2006)

Programma UE: SCIENZE DELLA VITA (2002-2006) - Qualità della vita e gestione delle risorse biologiche

Area Tematica:

Tipo Progetto: STREP - Progetti Specifici Mirati

Descrizione:

The overall objective is the development of ultra-sensitive bio-imaging techniques based on novel multifunctional nanoparticles (NPs) with tailored optical and magnetic properties for visualizing complex cellular structures, receptors, tumour cells and tissues. True innovation rests on the capability to combine the preparation of 'ad-hoc NPs, having different properties and functions, with the development of advanced bio-imaging techniques. The expected improvements of labelling cells and cellular structures with tailored NPs are sensitivity, speed and specificity in the visualization of biological systems. We plan the development of stable colloidal solutions containing non-cyto-toxic, colloidally stable Si-based NPs properly functionalised on the surface in order to improve and tune their optical properties and increase their selectivity in specific biological targets. These NPs will be employed, in cooperation with two SMEs, for the development of optical bio-imaging techniques aiming at: (i) understanding how the genome instructs and orchestrates the functions of cells, organs and organisms; (ii) whole-cell labelling for cell or pathogen detection, cell tracking, cell sorting and cell lineage studies; (iii) optical imaging of tumour cells for early cancer diagnostics. A further task concerns the development of stable colloids of non-toxic, non-immunogenic NPs with: (i) high magnetization, so that NP can be moved in the blood and accumulated in the target organ; (ii) particle size small enough to remain in circulation after injection; (iii) narrow size distribution for differential uptake of various tissues. The aim is the development of marketable, well-tolerated, highly efficient, specific and economically viable contrast agents for the detection and characterization of complex tumour and/or inflammatory lesions in Magnetic Resonance Imaging, in collaboration with our industrial partner.

Attività svolta da ENEA:

L'ENEA coordina il progetto. Synthesis of Si nanoparticles with controlled morphology by laser pyrolysis; optical and structural characterization of the produced nanoparticles; surface processing of the Si nanoparticles in order to tune the photoluminescence emission range and increase the emission intensity as required for bio-imaging techniques; preparation and characterization of colloidal suspensions of the processed nanoparticles to be delivered to the partners responsible for bio-compatibilization and evaluation of toxicity of the nanoparticles.

Note:

Posizione:
952

Codice Atto:


Atto di approvazione ENEA:
288/DG/2006

Unità alla stipula:
FIM

Costo eleggibile del Progetto: 4.213.725,00

Contributo al Progetto: 2.909.005,00

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Costo eleggibile per ENEA: 543.900,00

Contributo ad ENEA: 313.000,00

Anno di stipula:
2006

Durata in mesi:
0

Data di inizio:
01-11-2006

Data di scadenza:
31-10-2009