Banca Dati PROGETTI UE





 

DETTAGLI PROGETTO  PROCARDIO
(Num. 295823)


Num. Contratto:
 295823

Coordinatore: HELMHOLTZ-ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH (Germania)

Responsabile ENEA: SARAN ANNA - SSPT-TECS-TEB (CASACCIA)

Ruolo ENEA: PARTNER

Sito Web: Sito WEB non disponibile

Programma Quadro: Settimo Programma Quadro Euratom (2007-2013)

Programma UE: Euratom fissione - Fissione nucleare e radioprotezione

Area Tematica: Radioprotection

Tipo Progetto: CP-FP - Progetto di collaborazione-progetto mirato

Descrizione:

Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models. The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart are available. These data will be interrogated using new mathematical models developed from the data from our molecular and biological studies. These will use state-of-the-art technologies to map cardiovascular changes after photon irradiation at both low doses and low dose rates. This will be complemented by comparative studies using high LET irradiation. We will apply an integrative approach to combine transcriptional (mRNA and miRNA) and translational (proteomics) studies to understand the disease processes. High throughput proteomics (ICPL, SILAC and label-free analysis) will be used to identify new biomarkers of radiation-induced cardiovascular disease for future molecular epidemiological studies. These will be validated using the archives of cardiovascular tissue samples from the Mayak facility.


Attività svolta da ENEA:

L'ENEA coordina il Workpackage 5 "Effect of Dose Rate" e contribuisce al Workpackage 6 “Complex tissue interactions in radiation-induced vascular disease”.


Note:


Posizione:
 1181

Codice Atto:
 07O09

Atto di approvazione ENEA:
 659/2011/COMM

Unità alla stipula:
 UTBIORAD-RAB

Costo eleggibile del Progetto: 5.945.179,00

Contributo al Progetto: 2.998.386,00


Costo eleggibile per ENEA: 369.991,00

Contributo ad ENEA: 184.995,00

Anno di stipula:
 2011

Durata in mesi:
 36

Data di inizio:
 01-10-2011

Data di scadenza:
 31-03-2015


Indice                               Costo Tot. Contr. UE
               
0 SCK CEN - STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE Istituti di ricerca Belgio
1 INSTITUT GUSTAVE ROUSSY Istituti di ricerca Francia
2 GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O Società di consulenza Germania
3 GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH Istituti di ricerca Germania
4 HELMHOLTZ-ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Istituti di ricerca Germania COORD
5 ENEA Istituti di ricerca Italia PARTNER
6 RIVM - NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT Istituti di ricerca Paesi Bassi
7 UNIV. AMSTERDAM (UVA) Università Paesi Bassi
8 HPA - HEALTH PROTECTION AGENCY Istituti di ricerca Regno Unito
9 UNIV. BIRMINGHAM Università Regno Unito
10 FEDERAL STATE UNITARY ENTERPRISE SOUTHERN URALS BIOPHYSICS INSTITUTE OF FEDERAL MEDICOBIOLOGICAL AGENCY Istituti di ricerca Russia
11 CREAL FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL Istituti di ricerca Spagna

 Argomento  Macro Key  Keyword
Biological Sciences MEDICINE, HEALTH MEDICINE, HEALTH
Energy NUCLEAR FISSION NUCLEAR FISSION
Protecting Man and his Environment RADIATION PROTECTION RADIATION PROTECTION

 Indice
Low dose