Num. Contratto:
613513

Coordinatore: ROYAL ALLOWAY AND BEDFORD NEW COLLEGE (Regno Unito)

Responsabile ENEA: GIULIANO GIOVANNI - SSPT-BIOAG (CASACCIA)

Ruolo ENEA: PARTNER

Sito Web: http://www.disco-fp7.eu/

Programma Quadro: Settimo Programma Quadro R&ST (2007-2013)

Programma UE: Biotecn, prod.alim, agric., pesca (2007-2013) - Prodotti alimentari, agricoltura e pesca, e biotecnologie

Area Tematica: Life sciences - food genetic

Tipo Progetto: CP - Progetto di collaborazione

Descrizione:

Plant natural products have been utilised by human civilisation for millennia, providing vital medicines and essential dietary components. More recently bioactive compounds from plant sources have been used in cosmetics, as health supplements and are important components of feedstuffs. Despite significant investments new activities and new sustainable biosources are required to alleviate our reliance on chemical synthesis. In the DISCO project we aim to address these issues and create a framework that can act as a generic pipeline capable of taking discovery through application and validation, to translation and industrial valorisation. Key aspects of the project will be concerned with (i) translating discovery into industrial feasibility and/or commercialisation, (ii) transfer our knowledge gained optimising isoprenoid/terpenoid production to other important terpenoids and different classes of natural products, (iii) maintaining and incorporating the very latest technologies into both the discovery and translational pipelines and (iv) develop “green factories” with integrated biorefining pipelines to reduce or eliminate chemical refining and thus environmental impact. The bioactive molecules and their biochemical pathways targeted include, carotenoids (including apo-carotenoids), terpenoids and tropane alkaloid. For example; ketocarotenoids which are used as colorants in feedstuffs especially aquaculture; colourless carotenes such as phytoene and phytofluene, which are important bioactive ingredients of cosmetics; apo-carotenoids from saffron which are colorants and potent bioactives; the terpenoid solanesol which is used in the production of Coenzyme Q10 and the alkaloid scopolamine which is used as analgesic. The project will have real-life impacts reducing environmental impact, provide new material to benefit human activities and stimulate economic development.

Attività svolta da ENEA:

L'ENEA partecipa a tutti i workpackages e coordina il workpackage 2; in particolare le attività riguarderanno la biosintesi, regolazione e ingegneria metabolica degli apo-carotenoidi in zafferano, effettuerà screening metabolomici di specie Solanaceae e Iridaceae e svilupperà tecnologie abilitanti (trascrittomica, metabolomica) ed attività di formazione e divulgazione.

Note:

Posizione:
1305

Codice Atto:
07N72

Atto di approvazione ENEA:
546/2013/COMM

Unità alla stipula:
UTAGRI-GEN

Costo eleggibile del Progetto: 8.644.534,00

Contributo al Progetto: 6.485.847,00

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Costo eleggibile per ENEA: 583.127,00

Contributo ad ENEA: 437.845,00

Anno di stipula:
2013

Durata in mesi:
48

Data di inizio:
01-11-2013

Data di scadenza:
31-10-2017