Num. Contratto:
691238

Coordinatore: ENEA (Italia)

Responsabile ENEA: DI LUCCIO TIZIANA - SSPT-PROMAS-NANO (PORTICI (NA))

Ruolo ENEA: COORD

Sito Web: http://www.bi-stretch-4-biomed.com

Programma Quadro: HORIZON 2020

Programma UE: MSCA Marie Skl. Curie Actions - Marie Sklodowska Curie Actions

Area Tematica: Nanotechnology - materials

Tipo Progetto: MSCA RISE - Research and Innovation Staff Exchange

Descrizione:

New materials are now opening clinical treatments in which a temporary scaffold is used to support regeneration of healthy tissue. The specific need that inspires our research is for thinner and stronger bioresorbable vascular scaffolds (BVS) for coronary heart disease. BVS are poised to replace metal stents due to the excellent clinical outcomes: beyond keeping the vessel open during the first six months after surgery, the BVS leaves behind a healthy blood vessel after the scaffold is gone, being completely absorbed by the body approximately two years after surgery. The material that has achieved clinical approval for BVS is poly(L-lactic acid), PLLA. It is not as strong and stiff as metals, so the scaffold is three times thicker than the metal stents, making it more difficult for surgeons to move through arteries to reach the site of the lesion. Thinner Scaffolds that can be seen by x-ray imaging during surgery would facilitate adoption of the technology and benefit thousands of patients in the EU and US. The proposed Action will provide the fundamental understanding needed to reinforce PLLA by tungsten disulphide (WS2) nanotubes to achieve both the strength and x-ray opacity needed. Improving materials for BVS requires an interdisciplinary approach by materials science, polymer processing, and bioengineering. The proposed Action will connect EU scientists with a polymer scientist at Caltech in the US who has specialized knowledge of PLLA BVS and the relevant structure-processing-property relationships (Kornfield). European scientists bring expertise in WS2 nanotubes that are powerful additives for enhancing polymer properties (Di Luccio), compounding polymers with nanotubes (McNally), biaxial stretching to induce strength and orientation in polymers (Menary), multiscale modeling to connect nanoscale to continuum scale (Figiel), multimethod characterization of structure in nanocomposites (Schiller) and the response of cells to nanoparticles (Kornfield).

Attività svolta da ENEA:

L'ENEA coordina il progetto e svolge attività di ricerca dettagliate in task distribuite su sei work package.

Note:

Duplice Responsabile: Matr. 90459 - DI LUCCIO TIZIANA e Matr. 90528 - VILLANI FULVIA

Posizione:
1375

Codice Atto:
PS0AAB

Atto di approvazione ENEA:
503/2015/COMM

Unità alla stipula:
SSPT-PROMAS-NANO

Costo eleggibile del Progetto: 400.500,00

Contributo al Progetto: 342.000,00

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Costo eleggibile per ENEA: 139.500,00

Contributo ad ENEA: 132.800,00

Anno di stipula:
2015

Durata in mesi:
48

Data di inizio:
01-02-2016

Data di scadenza:
31-01-2020