Num. Contratto:
002/2016

Coordinatore: BFS - FEDERAL OFFICE FOR RADIATION PROTECTION (Germania)

Responsabile ENEA: MANCUSO MARIA TERESA - SSPT-BIOTEC (CASACCIA)

Ruolo ENEA: PARTNER

Sito Web: http://www.concert-h2020.eu/

Programma Quadro: HORIZON 2020 - Euratom

Programma UE: Euratom radioprotezione - Radioprotezione

Area Tematica: Radioprotection

Tipo Progetto: N/A - Non applicabile

Descrizione:

LDLensRad is a project financed by CONCERT - The European Joint Programme for the Integration of Radiation Protection Research - that aims to contribute to the sustainable integration of European and national research programmes in the field of radiation protection. The lens of the eye is known to be more radiosensitive than previously thought but, despite a substantial reduction in occupational dose limits based on recent epidemiological information and reanalyses, the biological mechanisms that cause low dose radiation cataract induction are still unclear. This is an important current public health issue, for instance for medical radiation workers, many of whom will need to amend their working practices despite the lack of a clear understanding of the effects of chronic, low dose, ionising radiation exposure. This multidisciplinary project aims to bring together experts from across Europe to answer a number of key research questions on this topic, including: how does low dose radiation cause cataracts; is there a dose rate effect, and how does genetic background influence cataract development after radiation exposure. The research will also address the issue of ageing in a sensitive subset of mice and whether lens effects can be viewed as global biomarkers of radiosensitivity. The partners will work with mouse models supported by cellular studies to investigate the mechanistic chain of events from the initial radiation insult and biological responses through to formation of lens opacities. The biological investigations will be supported by rigorous statistical modelling for hypothesis development. In addition, the partners will explore the potential for a prospective molecular epidemiology programme using human lenses taken from the former Mayak PA workers.

Attività svolta da ENEA:

Nell'ambito del progetto l'ENEA si occuperà di: . Irraggiare con diverse dosi e rateo di dose, modelli animali allo scopo di valutare i meccanismi molecolari coinvolti nell'insorgenza di cataratta a breve e a lungo termine; . irraggiare linee cellulari di lente, murine e umane, per studi molecolari in vitro a supporto degli studi in vivo; . Analizzare mediante un approccio immunoistochimico marcatori di neurodegenerazione allo scopo di valutare eventuali danni cerebrali negli animali irraggiati.

Note:

Posizione:
1451

Codice Atto:
PS5AAG

Atto di approvazione ENEA:
1072017/SSPT-TECS

Unità alla stipula:
SSPT-TECS-TEB

Costo eleggibile del Progetto: 2.467.290,00

Contributo al Progetto: 2.467.290,00

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Costo eleggibile per ENEA: 879.024,00

Contributo ad ENEA: 606.526,00

Anno di stipula:
2017

Durata in mesi:
39

Data di inizio:
01-01-2017

Data di scadenza:
31-03-2020